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. Author manuscript; available in PMC: 2023 Oct 31.
Published in final edited form as: Chem Soc Rev. 2022 Oct 31;51(21):9127–9173. doi: 10.1039/d2cs00618a

Figure 9. Different chemical modification strategies used to create gelatin-based bioadhesives.

Figure 9.

(A) Chemical synthesis route for the development of highly adhesive and strong hydrogels based on modified hyaluronic acid (HA) and gelatin methacryloyl (GelMA) and its application in sealing (B) heart- and (C) arterial-related incisions. Reproduced with permission from ref 121. Copyright 2019, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. (D) Ex vivo evaluation of the methacryloyl-substituted tropoelastin (MeTro) sealant for sealing pig lung. (E) The sealing pressure was increased significantly using a MeTro hydrogel at 20 wt.% pre-polymer concentration. (F, G) Application of MeTro for sealing rat artery, and (H) the burst pressure suggesting the MeTro hydrogel is on the same order as a healthy artery. From ref 213. Reprinted with permission from AAAS. (I) Synthesis of the MeTro and (J) GelMA pre-polymers for application on the wound site. (J) MeTro/GelMA hydrogels in a crosslinked network. Reproduced with permission from ref 230. Copyright 2017, Elsevier.