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. 2022 Dec 20;10:1083640. doi: 10.3389/fbioe.2022.1083640

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Copyright © 2022 Zhang, Gong, He, Khan, Xiong, Shen and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Utlization of MSCs derived exosomes for wound healing. (A) Depicts the light field photographs of cutaneous wounds post treatment with PBS, BMMSCs, BMMSC-ex, and BM/siRab27a. (B) Percentage of the wound closure on day 3–day 12 in reference to the day 0 wounds (n = 4). (C) qRT-PCR analysis of IL-10 and TNF-α in macrophages after being cocultured with BMMSC-, BMMSC/siRab27a-, or BMMSC-derived exosomes (n = 3). (D) qRT-PCR analysis of miR-223 in macrophages cocultured with BMMSCs, BMMSC-ex, and BM/siRab27a (He et al., 2019).