Table 2.
Subgroup and Sensitivity Analyses of Fibrosis and Serum Transaminases
| Analysis | Fibrosis | AST | ALT | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Trials (n) | SMD (95% CI) | I2 | Trials (n) | MD (95% CI) | I2 | Trials (n) | MD (95% CI) | I2 | |
| Subgroup analysis | |||||||||
| Adult | 1 | 0.23 (-0.36, 0.81) | NA | 1 | 1.97 (-3.58, 7.52) | NA | 2 | 1.11 (-4.62, 6.83) | 0 |
| Children | 1 | -0.18 (-0.72, 0.36) | NA | 2 | -0.59 (-3.45, 2.27) | 0 | 2 | 3.73 (-4.83, 12.29) | 0.85 |
| Sensitivity analysis | |||||||||
| Trials that explicitly reported means and SDs | 1 | 0.23 (-0.36, 0.81) | NA | 1 | 0.09 (-3.39, 3.57) | NA | 2 | -0.44 (-4.52, 3.63) | 0 |
| Trials without duplicated studies (Nobili et al., 2008) | 0 | NA | NA | 2 | 0.62 (-2.33, 3.57) | 0 | 3 | 0.05 (-3.29, 3.39) | 0 |
SMD, standardized mean difference; MD, mean difference; SD, standard deviation; AST, aspartate transaminase; ALT, alanine transaminase