TABLE 2.

Baseline thrombin generation kinetics, cfDNA, and histone levels for volunteers versus trauma patients

	Volunteers (n = 21)	Trauma (n = 46)	P
LT (min)	3.18 [2.67, 3.67]	3.11 [2.67, 3.52]	0.973
PH (nM)	227.3 [206.1, 288.7]	273.7 [230.7, 300.5]	0.084
ttPeak (min)	6.83 [5.67, 7.67]	6.00 [5.33, 6.67]	0.074
cfDNA (ng/mL)	438.8 [381.4, 502.3]	576.9 [503.3, 803.1]	< 0.001
CitH3 (ng/mL)	0.73 [0.40, 3.62]	4.54 [2.23, 10.01]	0.003
H4 (ng/mL)	0.96 [0.41, 91.25]	1.30 [0.64, 6.36]	0.752

LT, lag time; PH, peak height; ttPeak, time to peak; CitH3, citrullinated histone 3; H4, histone 4.

All values expressed as median and quartiles [Q1, Q3]. Wilcoxon rank-sum (unpaired) testing.

Significant P values (P < 0.05) appear in bold.