TABLE 3A.

Trauma patients (n = 46)—thrombin generation kinetics, cfDNA, and histone levels (+/−DNAse) for trauma patients (n = 46) with and without the addition of DNAse I (1,000 U/mL)

	(−) DNAse	(+) DNAse	Median difference	Median % change	P
LT (min)	3.11 [2.67, 3.52]	2.93 [2.67, 3.19]	−0.21	−5.9	< 0.001
PH (nM)	273.7 [230.7, 300.5]	288.7 [257.6, 319.2]	20.7	7.9	< 0.001
ttPeak (min)	6.00 [5.33, 6.67]	5.48 [5.00, 6.00]	−0.55	−8.6	< 0.001
cfDNA (ng/mL)	576.9 [503.3, 803.1]	456.0 [393.5, 626.7]	−133.4	−22.3	< 0.001
CitH3 (ng/mL)	4.54 [2.23, 10.01]	3.59 [1.93, 7.98]	−0.65	−14.4	< 0.001
H4 (ng/mL)	1.30 [0.64, 6.36]	1.75 [0.83, 9.67]	0.44	32.8	< 0.001

LT, lag time; PH, peak height; ttPeak, time to peak; CitH3, citrullinated histone 3; H4, histone 4.

All values expressed as median and quartiles [Q1, Q3]. Wilcoxon rank-sum (unpaired) testing.

Significant P values (P < 0.05) appear in bold.