TABLE 3B.

Volunteers (n = 21)—thrombin generation kinetics, cfDNA, and histone levels (+/−DNAse) for volunteers (n = 21) with and without the addition of DNAse I (1,000 U/mL)

	(−) DNAse	(+) DNAse	Median difference	Median % change	P
LT (min)	3.18 [2.67, 3.67]	3.22 [2.83, 3.50]	−0.02	−0.6	0.891
PH (nM)	227.3 [206.1, 288.7]	245.5 [208.0, 280.3]	7.6	2.0	0.284
ttPeak (min)	6.83 [5.67, 7.67]	6.33 [5.67, 7.22]	−0.36	−5.3	0.002
cfDNA (ng/mL)	438.8 [381.4, 502.3]	355.9 [297.0, 400.1]	−84.9	−20.3	< 0.001
CitH3 (ng/mL)	0.73 [0.40, 3.62]	0.63 [0.40, 3.31]	−0.11	−4.9	0.045
H4 (ng/mL)	0.96 [0.41, 91.25]	1.19 [0.57, 202.13]	0.24	42.8	0.002

All values expressed as median and quartiles [Q1, Q3]. Wilcoxon matched-pairs signed rank test.

Significant P values (P < 0.05) appear in bold.