TABLE 4.

Thrombin generation kinetics, cfDNA, and histone levels for volunteers versus trauma patients after incubation with DNAse (1,000 U/mL)

	Volunteers (n = 21)	Trauma (n = 46)	P
LT (min)	3.22 [2.83, 3.50]	2.93 [2.67, 3.19]	0.111
PH (nM)	245.5 [208.0, 280.3]	288.7 [257.6, 319.2]	0.017
ttPeak (min)	6.33 [5.67, 7.22]	5.48 [5.00, 6.00]	0.013
cfDNA (ng/mL)	355.9 [297.0, 400.1]	456.0 [393.5, 626.7]	< 0.001
CitH3 (ng/mL)	0.63 [0.40, 3.31]	3.59 [1.93, 7.98]	0.006
H4 (ng/mL)	1.19 [0.57, 202.13]	1.75 [0.83, 9.67]	0.844

LT, lag time; PH, peak height, ttPeak, time to peak; CitH3, citrullinated histone 3; H4, histone 4.

All values expressed as median and quartiles [Q1, Q3].Wilcoxon rank sum (unpaired) testing.

Significant P values (P < 0.05) appear in bold.