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. 2022 Dec 22;31(1):89–96. doi: 10.4062/biomolther.2022.137

Fig. 5.

Fig. 5

Schematic view for melanogenesis induced by uric acid upregulated in GDA-overexpressing keratinocytes. Uric acid produced by GDA upregulation in keratinocytes could enhance MITF and tyrosinase expression via bFGF and SCF production without going through ROS generation.