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. Author manuscript; available in PMC: 2023 Mar 23.
Published in final edited form as: Neuromolecular Med. 2022 Jun 24;25(1):27–39. doi: 10.1007/s12017-022-08713-2

Fig. 5.

Fig. 5

SIRT3 haploinsufficiency exacerbates Aβ accumulation in the cerebral cortex and hippocampus of AppPs1 mutant mice. A, B Confocal images showing Aβ immunoreactivity in the cerebral cortex and hippocampal regions of App/Ps1 and App/Ps1 Sirt3± mice at 8 months (A) and 12 months (B) of age, respectively. Coronal brain slices were stained for with Aβ antibody 6E10 (green) and cell nuclei were counterstained with propidium iodide (red) or DAPI (blue). C, D Quantitative analysis of Aβ load in matching cortical (C) and hippocampal (D) regions. Values are mean ± SEM (n = 6–12 brain slices analyzed from 3 to 6 mice). **p < 0.01 (two-way ANOVA followed by Tukey post hoc tests)