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. 2022 Dec 15;24(1):69–83. doi: 10.1038/s41590-022-01370-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a,b, Descriptive statistics for included clinical cohorts. After correcting for study, TCGA and BEAT data were integrated into an adult cohort (a). All of the pediatric data came from the TARGET database (b). Distribution of MECOM expression, MECOM NES and LSC17 score are displayed for each clinical dataset. c–g, Kaplan–Meier (KM) overall survival curves for adult and pediatric AML cohorts stratified by MECOM expression (c), MECOM network enrichment (d), MECOM NES (e), clinical risk group (f) and LSC17 (g). For continuous variables in c,e,g optimal threshold was determined by maximizing sensitivity and specificity on mortality (Youden’s J statistic). HRs were computed from univariate Cox proportional hazard models. P values representing the result of Mantel–Cox log-rank testing are displayed. Test for trend was performed for clinical risk group stratification (more than two groups). h,i, KM overall survival curves stratified by current prognostic tools and MECOM down network status. MECOM network enrichment was significantly associated with mortality independent of clinical risk group in adult (P = 0.005) and pediatric (P = 0.008) AML (h) and independent of LSC17 score in adult (P = 0.01) and pediatric (P = 0.01) AML (i). j,k, Marginal hazard of death associated with increasing MECOM expression (j) and MECOM network enrichment score (k), stratified by age. 95% confidence interval of death is shown in the shaded regions. P values representing the significance of MECOM expression and MECOM network enrichment on survival were calculated using two-sided multivariable Cox proportional hazards modeling, adjusted for age and sex.