Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 20;14:1069482. doi: 10.3389/fnagi.2022.1069482

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Aversano, Caiazza and Caiazzo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The epigenetic landscape in aging. Aging causes both global and locus-specific changes to chromatin structure. The aging process is characterized by global DNA hypomethylation except in CpG islands that become hypermethylated at promoter regions of tissue-specific genes. Moreover, there is a decrease in global heterochromatin along with a reduction in heterochromatin protein 1 (HP1) and in repressive histone mark H3K9me3.