Table 2.
Time from birth and the 1st and 2nd dose of caffeine and caffeine blood level measured 60 ± 15 min after the 1st dose and 60 ± 15 min before the second dose
| Intravenous caffeine (n = 19) | Enteral caffeine (n = 19) | p value | |
|---|---|---|---|
| Time from birth to 1st caffeine dose (min) | 7.6 ± 1.3 | 7.1 ± 2.0 | 0.367 |
| Time from birth to 1st caffeine level measurement (min) | 61.1 ± 3.0 | 61.4 ± 2.7 | 0.748 |
| Caffeine blood level 60 ± 15 min after administration in the DR (µg/mL) | 9.1 ± 5.2 | 8.3 ± 4.1 | 0.602 |
| Caffeine blood level < 5 µg/mL | 6/19 (32) | 3/17 (18) | 0.451 |
| Caffeine blood level > 20 µg/mL | 1/19 (5) | 0 | 1.000 |
| Time from birth to 2nd caffeine dose (h) | 23.5 ± 7.1 | 25.5 ± 2.3 | 0.250 |
| Time from birth to 2nd caffeine level measurement (h) | 22.0 ± 5.4 | 23.1 ± 0.5 | 0.383 |
| Caffeine blood level 60 ± 15 min before the second dose (µg/mL) | 5.0 ± 1.3 | 5.1 ± 1.0 | 0.792 |
| Caffeine blood level < 5 µg/mL | 2/16 (13) | 4/17 (24) | 0.656 |
| Caffeine blood level > 20 µg/mL | 1 (5) | 0 | 1.000 |
Mean ± standard deviation (SD)
DR delivery room, SD standard deviation