Table 2.

Serum AMH levels and antral follicle count (AFC) in BRCA mutation carriers and controls

	BRCA mutation carrier (n = 36)	Sig.*	BRCA1 mutation carrier (n = 18)	Sig.*	BRCA2 mutation carrier (n = 18)	Sig.*	Control (n = 126)
Unadjusted serum level AMH (ng/ml) median (IQR)	2.40 (1.80–3.00)	0.45	2.40 (1.73–2.85)	0.85	2.45 (1.78–3.23)	0.34	2.15 (1.35–3.40)
Linear regression model
Geometric mean ratio (95% CI)
BRCA carrier status, unadjusted	1.03 (0.34–3.19)	0.56	1.00 (0.31–5.37)	0.99	1.07 (0.34–3.49)	0.39
BRCA carrier status, age-adjusted	1.03 (0.34–3.19)	0.55	1.02 (0.32–3.25)	0.83	1.05 (0.33–3.39)	0.49
BRCA carrier status, fully-adjustedb	1.01 (0.33–3.10)	0.94	0.98 (0.30–3.82)	0.76	1.03 (0.32–3.32)	0.67
	BRCA mutation carrier (n = 30)	Sig.*	BRCA1 mutation carrier (n = 15)	Sig.*	BRCA2 mutation carrier (n = 15)	Sig.*	Control (n = 122)
Unadjusted AFC median (IQR)	15.0 (10.8–20.3)	0.54	14.0 (10.0–20.0)	0.86	15.0 (12.0–28.0)	0.27	14.5 (9.0–20.0)
Linear regression model
Coefficienta, β (95% CI)
BRCA carrier status, unadjusted	0.18 (− 0.26–0.61)	0.42	− 0.09 (− 0.67–0.50)	0.77	0.44 (− 0.14–1.03)	0.14
BRCA carrier status, age-adjusted	0.17 (− 0.26–0.60)	0.43	− 0.08 (− 0.66–0.49)	0.77	0.43 (− 0.15–1.01)	0.14
BRCA carrier status, fully-adjustedb	0.17 (− 0.28–0.62)	0.46	− 0.09 (− 0.69–0.52)	0.78	0.42 (− 0.18–1.01)	0.17

AMH, anti-Mullerian hormone; AFC, antral follicle count; IQR, interquartile range; CI, confidence interval. Median AFC (2–10 mm) in both ovaries assessed using a standard transvaginal sonography (TVS). *P-values comparing AMH or AFC in carriers vs controls, calculated using Mann Whitney U. ^aEstimated coefficient (β) of BRCA carrier status on the natural logarithm of AMH serum levels, retransformed into the original scale (Exp(β)) or estimated coefficient of BRCA carrier status on square-root transformed AFC. ^bAdjusted for age, BMI, gravidity, smoking and oral contraceptive use in downregulation