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. 2023 Jan 3;14:8. doi: 10.1038/s41467-022-35431-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Pairwise overlap circos plot showing total numbers of clonotypes shared between samples in 16 patients. b Abundances of top 20 most frequent TCR clonotypes in each patient pre- and post-treatment. c Correlation between clone expansion scores (CE scores) and percentages of pathological regression. The correlation was accessed by Spearman’s rank correlation coefficient (rho). The regression line is red and the shading indicates the 95% confidence interval. d Proportion of four TCR clonotypes classified by their frequency (hyperexpanded, >0.01 and ≤1; large, >0.001 and ≤0.1; medium, >0.0001 and ≤0.001; small, ≤0.0001). Black lines highlight changes in proportions of hyperexpanded clones. e Changes in four TCR clonotypes from pre- to post-treatment in PPR+ (top, n = 4) and non-PPR+ (bottom, n = 6) patients. Two-sided Wilcoxon signed-rank test was used for comparison. f-g Differences of TRBV (f) and TRBJ (g) segment usages from pre- to post-treatment samples. Source data are provided as a Source Data file.