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. 2023 Jan 2;33(1):46–54. doi: 10.1038/s41422-022-00751-6

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Fig. 4 — a–c Structural alignment of the active MC2R with active and inactive MC4R (PDB codes: 7F53, 6W25). Side view (a); extracellular view (b); cytoplasmic view (c). d Steric hindrance effect of ACTH-F7 on TM1 and TM2 of MC2R. e–i Conformational changes of MC2R upon activation indicating a conserved activation mechanism across the MCR family. Toggle switch (e, f), MIF motif (g), DRY motif (h), and DPxxY motif (i) are shown.