Table 4.
Effects of bepotastine on memory, psychomotor functions, sleep and mood
| Baseline | 1 week | 4 week | ||||
|---|---|---|---|---|---|---|
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| Mean | SEM | Mean | SEM | Mean | SEM | |
| Remote memory | 8 | 0 | 7.39* | 0.231 | 7.94# | 0.056 |
| Recent memory | 4.89 | 0.076 | 4.94 | 0.056 | 4.94 | 0.056 |
| Mental Balance | 4.5 | 0.55 | 4.28 | 0.636 | 4.22 | 0.613 |
| Attention and concentration | 3.78 | 0.552 | 3.5 | 0.414 | 3.83 | 0.493 |
| Delayed recall | 8.44 | 0.372 | 8.33 | 0.45 | 8.5 | 0.345 |
| Immediate recall | 6.5 | 0.682 | 6.17 | 0.612 | 6.72 | 0.516 |
| Verbal retention of similar pairs | 3.83 | 0.167 | 4.11 | 0.159 | 4.11 | 0.196 |
| Verbal retention of dissimilar pairs | 8.89 | 0.816 | 9.06 | 0.906 | 10#,@ | 0.82 |
| Visual retention | 6.83 | 0.48 | 7.5 | 0.525 | 7.78 | 0.558 |
| Recognition | 8.06 | 0.521 | 8.22 | 0.552 | 8.56#,@ | 0.55 |
| PGIMS score | 63.72 | 1.97 | 63.5 | 2.43 | 66.61# | 2.416 |
| Single letter cancellation test | 22.17 | 1.253 | 23.72 | 1.643 | 24 | 1.563 |
| Digit letter substitution test | 19.78 | 1.689 | 19.94 | 2.173 | 20.17 | 1.844 |
| Choice reaction time audio | 1.51 | 0.09593 | 1.37507 | 0.076186 | 1.39339^ | 0.074468 |
| Choice reaction time video | 1.4 | 0.11132 | 1.37507 | 0.076186 | 1.39339 | 0.074468 |
| Hand steadiness test | 61.15 | 9.42 | 58.2 | 9.86 | 53.35 @ | 8.01 |
| Critical flicker fusion threshold at 20 Hz | 47.64 | 0.14 | 47.78 | 0.19 | 47.64 | 0.14 |
| Critical flicker fusion threshold at 50 Hz | 47.64 | 0.14 | 47.64 | 0.14 | 47.64 | 0.14 |
| Epworth sleepiness scale | 4.72 | 0.69 | 5.89 | 0.69 | 5.06 | 0.569 |
| Pleasant unpleasant score | 53.22 | 2.209 | 54.39 | 1.753 | 53.72 | 1.604 |
| Arousal calm score | 28.94 | 0.857 | 27.11* | 0.766 | 26.67@ | 0.804 |
| Positive tired score | 22.5 | 0.857 | 21.72 | 0.804 | 20.89@ | 0.9 |
| Negative relaxed score | 9.11 | 0.976 | 7.67 | 0.695 | 7.44 | 0.677 |
Footnote: Paired sample t-test was used for intragroup comparison. Here, * depicts significance at 1 week as compared to baseline, # depicts significance at 4 week as compared to 1 week, @ depicts significance at 4 week as compared to baseline. The shaded area represents the difference observed in intragroup comparison and ^ depicts significance at 4 week