Figure 3.

Risk of MI and stroke with tofacitinib versus TNFi by history of ASCVD. (A) HRs are shown on a logarithmic scale. Arrows indicate that the CI extends beyond the graph axis. For patients randomised to the tofacitinib 10 mg two-times-per-day group who had their dose of tofacitinib reduced to 5 mg two times per day, the data collected after patients were switched to tofacitinib 5 mg two times per day were counted in the tofacitinib 10 mg two-times-per-day group. HRs (95% CIs) are based on two simple Cox proportional hazard models (one for comparing combined tofacitinib doses vs TNFi, and the other for comparing tofacitinib 5 mg and 10 mg two times per day vs TNFi), with treatment as the only covariate. IRs express the number of patients with first events per 100 PY. (B) Treatment-by-HxASCVD interaction p values for HRs (χ² test with 1 degree of freedom) and IRD (two-sided, normal approximation of difference in IR). See supplementary material for details. BID, two times per day; CI, confidence interval; CV RF, cardiovascular risk factor; HxASCVD, history of atherosclerotic cardiovascular disease; IR, incidence rate; IRD, incidence rate difference; MI, myocardial infarction; n, number of patients with events; N, number of evaluable patients; PY, patient-years; TNFi, tumour necrosis factor inhibitor.