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. 2022 Dec 21;13:1072040. doi: 10.3389/fphys.2022.1072040

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Copyright © 2022 Vechetti, Norrbom, Alkner, Hjalmarsson, Palmcrantz, Pontén, Pingel, von Walden and Fernandez-Gonzalo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular vesicles microRNA cargo differences between cerebral palsy (CP) and typically developed (TD) individuals before (pre exercise) and 30 min after (post exercise) a bout of aerobic exercise. (A,C); volcano plots illustrating changes in EV cargo between TD and CP before (A) and after (C) exercise. Each point on the scatter plot represents a microRNA where its position on the x-axis corresponds to the average log2-fold change after exercise and the position on the y-axis corresponds to log10 p-value of its differential expression after adjustment for false discovery rate. (B,D); bar graphs illustrating the expression of selected microRNAs in CP individuals relative to TD participants before (B) and after (D) exercise; **; p < 0.01, *; p < 0.05.