TABLE 3.
Number of genes whose expression was significantly (FDR<0.05, FC ± 1.2) (CAS# 58–08-2), TB (83–67-0), TP (CAS# 58–55-9) or PX (CAS# 611–59-6) in each of the cell types evaluated.
| Number of genes whose expression was modified by each chemical a | |||||
|---|---|---|---|---|---|
| Chemical | Concentration (μM) | A549 | iCAR | HepG2 | MCF7 |
| Caffeine | 1,000 | 60 | 977 | 266 | 480 |
| Caffeine | 500 | 35 | 0 | 23 | 274 |
| Caffeine | 50 | 0 | 3 | 0 | 1 |
| Theobromine | 1,000 | 77 | 23 | 157 | 31 |
| Theobromine | 500 | 2 | 10 | 26 | 1 |
| Theobromine | 50 | 0 | 2 | 0 | 3 |
| Theophylline | 1,000 | 225 | 1,060 | 609 | 350 |
| Theophylline | 500 | 42 | 5 | 118 | 40 |
| Theophylline | 50 | 3 | 0 | 271 | 0 |
| Paraxanthine | 1,000 | 45 | 28 | 283 | 159 |
| Paraxanthine | 500 | 3 | 3 | 28 | 15 |
| Paraxanthine | 50 | 36 | 0 | 0 | 1 |
a
FDR <0.05.