Fig. 3.

PBMC responses to WT and deamidated C-peptide variants. (A) Proliferation in responses, measured as a cell division index (CDI) to WT or QallE C-peptide were compared in 8 PBMC from 8 people with recent onset T1D. Responses from the same individual are linked. There was no statistically significant difference between the groups. (B) PBMC proliferation responses to WT and C-peptide variants with individual Q to E substitution and QallE from people with recent onset T1D (B) and HLA matched control subjects who don't have T1D (C). Only difference which reached statistical significance are marked (* = P < 0.05). For responses in subjects without T1D, none of the differences between groups reached statistical significance, p > 0.05, by Wilcoxon matched pairs signed rank test of Log 10 transformed CDI data. Each point is a different individual, bars show the mean and the standard deviation for each group.