Table 3.
Overview of associations between polygenic risk scores and cortical complexity
| Coordinates | Anatomical region according to DK-40 | k | F | p (α = 0.001) |
p (FWE) (α = 0.00625) |
|||
|---|---|---|---|---|---|---|---|---|
| Polygenic risk for major depressive disorder | ||||||||
| Left hemisphere | −28 | 33 | −12 | Orbitofrontal | 20 | 11.15 | 0.000897 | 0.606 |
| Right hemisphere | 24 | 33 | −12 | Orbitofrontal | 453 | 21.69 | 0.0000039 | 0.006 |
| 28 | −98 | −9 | Lateral occipital | 133 | 12.7 | 0.0003968 | 0.364 | |
| Polygenic risk for cross-disorder | ||||||||
| Left hemisphere | −36 | 26 | 43 | Caudal middle frontal | 67 | 11.71 | 0.0006657 | 0.515 |
| Right hemisphere | 49 | −78 | 4 | Lateral occipital | 234 | 16.96 | 0.0000437 | 0.063 |
| Polygenic risk for schizophrenia | ||||||||
| Left hemisphere | – | – | – | No suprathreshold clusters | – | – | – | – |
| Right hemisphere | 12 | 30 | −26 | Lateral orbitofrontal | 121 | 12.36 | 0.0004744 | 0.411 |
| 28 | −60 | 4 | Lingual (93%), precuneus (7%) | 69 | 11.81 | 0.0006327 | 0.491 | |
| Polygenic risk for bipolar disorder | ||||||||
| Left hemisphere | – | – | – | No suprathreshold clusters | – | – | – | – |
| Right hemisphere | – | – | – | No suprathreshold clusters | – | – | – | – |
Note p and p (FWE) are shown at cluster-level and k refers to the cluster size at uncorrected thresholds. Significance thresholds were set at α = 0.001 and α = 0.00625 when correcting for multiple testing. Multiple regressions were performed using the following covariates: age, quadratic age, gender, site, MRI scanner, and three MDS-components. Bold indicates statistically significant results after applying FWE-correction. Cluster labeling was executed with the Desikan-Killiany-40 atlas (Desikan et al., 2006).