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. 2022 Mar 2;43:219–231. doi: 10.1016/j.jare.2022.02.015

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© 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Crocin improved adult neurogenesis in the hippocampus. (A) Time line of BrdU injection and drug treatment. (B) Dividing cells (arrows) were identified using Ki67 immunohistochemistry in crocin-treated or control group. Scale bar: 100 μm. (C) BrdU immunohistochemistry (gray-brown) was used for detecting 2-week survival cells (arrows), Scale bar: 100 μm. (D) Representative images of DG area showed four types of cells: BrdU⁺ cells (green) which co-express strong DCX (red) or NeuN (blue); BrdU unlabeled DCX⁺/NeuN⁺ immature neurons (denoted by solid arrows); BrdU unlabeled DCX^- /NeuN⁺ mature neurons (denoted by hollow arrow). (E-G) Quantification of Ki67⁺, total BrdU⁺ and NeuN⁺/DCX^-/NeuN⁺ cells. (H) The percentage of DCX^- /NeuN⁺ mature neurons in crocin-treated group or control group. Results are presented as mean ± SEM. Unpaired student’s t-test. *p < 0.05; ns, no significance.