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. 2022 Mar 2;43:219–231. doi: 10.1016/j.jare.2022.02.015

Fig. 8.

Fig. 8

Effects of crocin on depressive-like behaviors and adult hippocampal neurogenesis in CUMS-induced mice. (A) Timeline of CUMS experiment. (B) The body weight of mice in control, CUMS, CUMS treated with Flx (20 mg/kg) or CUMS treated with crocin (25 mg/kg). Body weight was measured for 6 weeks. (C) Sucrose preference rate of mice in each group. (D-E) The immobility time (TST and FST) of mice in four groups were quantified. (F-I) Crocin reversed CUMS-induced decline of Ki67+ cells, BrdU+ cells, NeuN+/DCX+/BrdU+ cells and mature neurons (NeuN+/DCX-/BrdU+) in DG area. (J-M) Effects of crocin treatment on Wnt3a, p-β-catenin and p-GSK3β protein levels in the hippocampus of CUMS mice. Results are presented as mean ± SEM. Results are presented as mean ± SEM. One-way ANOVA followed by Bonferroni post hoc test. CUMS vs Control, #p < 0.05; ##p < 0.01; Crocin vs CUMS, *p < 0.05; **p < 0.01.