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. 2022 Mar 12;43:163–174. doi: 10.1016/j.jare.2022.03.004

Fig. 2.

Fig. 2

Impact of sEH-P KI rats on sEH-H and sEH-P substrates and metabolites. a, Heat map shows the differences in the levels of lysophosphatidic acids (LPAs) and monoacylglycerols (MAGs), carrying linoleic (16:0), stearic (18:0), oleic (18:1), linoleic (18:2), arachidonic (20:4) or docosahexaenoic (22:6) acids, quantified in the plasma of 22-week old male and female sEH-P KI and WT rats. Mean values of the male WT group have been used as reference values (see Supplemental Figure 1a-b for numerical values). ND: not detected. b, c, Fold change in LPA-to-MAG ratio quantified in the plasma of 22-week old male (b) and female (c) sEH-P KI and WT rats. d, Heat map shows the differences in the levels of epoxyeicosatrienoic acid (EET) regioisomers, 12,13-epoxyoctadecenoic acid (12,13-EpOME), 19,20-epoxydocosapentaenoic acid (19,20-EpDPA), dihydroxyeicosatrienoic acid (DHET) regioisomers, 12,13-dihydroxyoctadecenoic acid (12,13-DiHOME) and 19,20-dihydroxydocosapentaenoic acid (19,20-DiHDPA) quantified in the plasma of 22-week old male and female sEH-P KI and WT rats. Mean values of the male WT group have been used as reference values (see Supplemental Figure 1c-d for numerical values). e, f, Fold change in EET-to-DHET, 19,20-DiHDPA-to-19,20-EpDPA and 12,13-DiHOME-to-12,13-EpOME ratios quantified in the plasma of 22-week old male (e) and female (f) sEH-P KI and WT rats. b, c, e, f, Mean values are shown. P values represent the genotype effect determined by two-tailed unpaired Student's t-test or by Mann-Whitney U test for non-normally distributed data (P < 0.05 on Shapiro-Wilk test). *P < 0.05, **P < 0.01.