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. 2022 Mar 5;43:175–186. doi: 10.1016/j.jare.2022.03.003

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© 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Pharmacological inhibition and genetic knockdown of iNOS ameliorate the HFpEF phenotype in mice. (A) Typical images of the left-ventricular M−mode echocardiogram of mice in different experimental groups. (B-C) The heart rate (B) and left-ventricular ejection fraction (LVEF) (C) was assessed using echocardiographic analyses. (D) Typical pulsed-wave Doppler images and tissue Doppler traces of mice in different experimental groups. (E) Mitral E to A-wave (E/A) ratios. (F) Mitral E to E’-wave (E/E’) ratios. (G-H) The change of Body weight and systolic pressure (SBP) between groups. n = 6. The data are shown as mean ± SEM and were analyzed using two-way ANOVA with Bonferroni post hoc test. *, P < 0.05. **, P < 0.01. ****, P < 0.0001. ns, no significant.