Fig. 6.
Intrathecally overexpressing GPX4 in SOD1G93A mice improved the GCM fibrillation and fasciculation, and blocked spine atrophy. a Fibrillation and fasciculation recordings in the GCM of G93A mice administrated with AAV and GPX4-AAV. b Quantitative analysis of the integrated EMG signals. N = 5 mice each group. c, d Representative MRI images and volume analysis of the lumbar GM region and the lumbar WM region. N = 3 mice each group. e Representative FA maps of lumbar spinal cord. Colors represent FA values, where on pink & purple shows lower FA values and on blue & cyan displays higher FA values. f, g Quantitative values of FA and MD in the GM and WM of lumbar VH. N = 5 mice each group. Data are represented as mean ± SEM. *p < 0.05, ***p < 0.001 G93A + EGFP-AAV vs. WT + EGFP-AAV group; #p < 0.05, ###p < 0.001 G93A + GPX4-AAV vs. G93A + EGFP-AAV group by One-way ANOVA. FA: fractional anisotropy, MD: mean diffusivity. WM: white matter, indicated by ellipse. GM: gray matter, indicated by pentagram. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)