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. 2022 Dec 21;12:1080985. doi: 10.3389/fonc.2022.1080985

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Copyright © 2022 Liu, Lin, Yang, Shao, Zhao, Wang and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of cuproptosis-related signature via LASSO-stepwise algorithms. (A, B) LASSO analysis with minimal lambda value. (C) Five genes were screen out by stepwise Cox algorithm. (D) Coefficients of 5 cuproptosis-related genes finally obtained in stepwise Cox regression. (E) The time-dependent ROC curve for Lasso-stepwise signature. (F) The ROC curve for LASSO-stepwise signature. (G) MRNA expression values in paired samples in TCGA. (H) Protein expressions of 5 differentially expressed cuproptosis-related signature in the tumor and normal tissues from the Human Protein Atlas platform.