Figure 5.

NPP-669 inhibits the replication of HAdV-C6 in the liver of immunosuppressed Syrian hamsters and prevents the resulting pathology. (A) Survival. (B) Body weight changes. The symbols represent the group average, and the error bars show the standard error. No group average was calculated after an animal was sacrificed from a given group. (C) Infectious virus load in the liver. (D) Serum alanine transaminase levels. For (C,D), the symbols represent values from individual animals; the horizontal bar shows the group mean, and the error bars depict the standard deviation. Empty symbols for the HAdV-C6 + vehicle and HAdV-C6 + NPP-669 0.1 mg/kg groups signify that the samples were collected from an animal that was sacrificed ahead of schedule for humane reasons. NQ: not quantifiable; ND: not detectable; for statistical analysis, treatment groups were compared to untreated infected groups. *: p < 0.05, **: p < 0.01, and ***: p < 0.001.