Table 1. Hepatocyte Clearance.
compound ID | N | clearance (μL/min/million cells) | half-life (min) |
---|---|---|---|
BCV | C16 | 9.73 | 142 |
NPP-662 | C10 | 18.8 | 73.8 |
NPP-663 | C10 | 22.2 | 62.4 |
NPP-664 | C12 | 60.6 | 22.9 |
NPP-666 | C12 | 14.7 | 94.3 |
NPP-667 | C14 | 154 | 9.01 |
NPP-669 | C13 | 6.85 | 202 |
NPP-670 | C12 | 33.3 | 41.6 |