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. 2022 Dec 9;20(1):370–382. doi: 10.1021/acs.molpharmaceut.2c00668

Table 3. PK Parameters of Prodrugs in Mice Following a Single Intravenous (IV) Dose.

  dose (mg/kg) Cmax (ng/mL) AUC (ng·h/mL) T1/2 (h) Cl (mL/min/kg) Vd (L/kg)
BCV 1 491 171 0.4 122 3.7
NPP-663 (C10) 3 1155 333 0.2 152 2.8
NPP-666 (C12) 3 1693 523 0.4 104 4.2
NPP-669 (C13) 3 2617 807 0.7 64 4.0