Table 3. PK Parameters of Prodrugs in Mice Following a Single Intravenous (IV) Dose.
dose (mg/kg) | Cmax (ng/mL) | AUC (ng·h/mL) | T1/2 (h) | Cl (mL/min/kg) | Vd (L/kg) | |
---|---|---|---|---|---|---|
BCV | 1 | 491 | 171 | 0.4 | 122 | 3.7 |
NPP-663 (C10) | 3 | 1155 | 333 | 0.2 | 152 | 2.8 |
NPP-666 (C12) | 3 | 1693 | 523 | 0.4 | 104 | 4.2 |
NPP-669 (C13) | 3 | 2617 | 807 | 0.7 | 64 | 4.0 |