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. 2022 Nov 14;20(1):183–193. doi: 10.1021/acs.molpharmaceut.2c00548

Figure 2.

Figure 2

Five compounds selected from the docking library inhibit the aggregation of α-synuclein. (A) Kinetic profiles of a 10 μM solution of α-synuclein in the presence of 25 nM seeds at pH 4.8 and 37 °C, in the presence of 1% DMSO alone (beige), in the presence of 10 molar equivalents of compounds A–E (represented in different colors), or in the presence of 10 molar equivalents of other compounds in the docking library that did not affect significantly α-synuclein aggregation (black). (B) Relative t1/2 of the aggregation of α-synuclein in the presence of compounds A–E as shown in (A), normalized to the DMSO control. (C) Chemical structures of compounds A–E. Throughout, error bars represent mean ± SEM of two replicates.