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. 2022 Nov 22;10(1):2204463. doi: 10.1002/advs.202204463

Figure 2.

Figure 2

Mysm1 knockdown alleviates depression‐like behaviors and murine osteoporosis. A) The experimental paradigm of virus infection for the treatment of depressive mice after CRS and LPS exposure. B) Immunofluorescence staining and C) qRT‐PCR results of Mysm1 in the MHb of AAV‐CMV‐Cre knockdown depressive mice. Scale bars, 20 µm, Behavioral effects of Mysm1 knockdown in the MHb of D) the CRS mouse model and E) the LPS mouse model in the TST and FST. F) Behavioral effects of Mysm1 knockdown in the MHb of the female CRS mouse model in the TST and FST. Behavioral effects of Mysm1 knockdown in the G) HIP and H) IC of the CRS mouse model in the TST and FST. I) 3D reconstruction results of µCT analysis of femoral trabecular bone in depressive mice (n = 4) after down‐regulation of Mysm1 in MHB. J) Analysis of µCT data showing BV/TV, Tb.N, Tb.Th and Tb.Sp in depressive mice after down‐regulation of Mysm1 in MHb. K) 3D reconstruction results of µCT analysis of femoral trabecular bone in depressive mice (n = 4) after down‐regulation of Mysm1 in HIP. L) Analysis of µCT data showing BV/TV, Tb.N, Tb.Th and Tb.Sp in depressive mice after down‐regulation of Mysm1 in HIP. Data represent the mean ± SEM; ns, not significant; *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.