Figure 7.

Inhibition of Mysm1 expression by aspirin alleviated murine depression‐like behaviors. A) Western blot of Mysm1 protein levels in cultured astrocytes treated with the indicative doses of aspirin. B) ATP levels in cultured astrocytes treated with the indicative doses of aspirin. C) Western blot of indicative proteins in cultured astrocytes treated with aspirin. D) Schematic diagram of aspirin treatment in CRS mice and the behavior tests. E) The TST and FST of CRS mice microinjected with saline or with aspirin at 12.5 µg µL⁻¹. F) Representative electron microscope images of mitochondria in the MHb from CRS mice microinjected with saline or with aspirin and the number of mitochondria, aspect ratio and shape factor were quantified. Scale bar, 100 µm. Data represent the mean ± SEM; ns, not significant; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.