Table 2.

Micelle Hydrogels for Drug Delivery

Hydrogel Composition	Micelle Composition	Drug	Disease	Release	Release Profile	Method of Administration	Ref.
α-cyclodextrin	polyethylene glycol-b-polycaprolactone, polyethylene glycol-b-polyacrylic acid	Doxorubicin, cisplatin	Cancer	Micelles are released from the hydrogel with degradation, then drugs encapsulated in the micelles are released via diffusion	Cumulative release of DOX is reduced from 100% to 28% at 168 hours via cyclodextrin/micellar hydrogel	Injection	(Poudel et al., 2018)
α-cyclodextrin	methoxy poly(ethylene glycol) block polymer	Diclofenac	Eye disease	Shear from blinking degrades the hydrogel and micellar drugs escape	Cumulative release of drug in solution is 95% at 12 hours, is extended to at least 91% at 216 hours using micellar hydrogel	Topical	(Z. Zhang et al., 2016)
N/A	methacrylated inulin/vitamin E	Beclomethasone dipropionate	Crohn’s disease	Drug release is mainly dependent on the swelling behavior of the gels, which is impacted by UV crosslinking time	Cumulative release reaches 60% at 120 hours using nanogrids	N/A	(Mandracchia et al., 2018)
N/A	alginate-g-poly(N-isopropylacrylamide)	Doxorubicin	Cancer	As the hydrogel undergoes dissolution, micelles are released, and the drug diffused to the target in a sustained manner	Release of DOX is sustained up to 500 hours in vitro	Injection	(Min Liu et al., 2017)
Carboxymethyl chitosan	poly (ethylene oxide)/poly (propylene oxide)/poly (ethylene oxide)	Glutaraldehyde	Eye disease	Hydrogel properties are governed by pH and temperature, resulting in different release profiles because of differences in swelling and porosity	Cumulative release of drug solution reached 100% at 72 hours, is reduced to 80% at 72 hours with micellar gel	Topical	(S. Yu et al., 2017)
Quaternized chitosan	poly(ethylene oxide)-b-poly(propylene oxide)-bpoly(ethylene oxide)	Curcumin	Infection	The hydrogel matrix and crosslinking point Schiff base are pH sensitive, enabling drug release when in contact with the acidic environment of wounds	Release of Curcumin is sustained up to 300 hours in vitro depending on pH	Injection	(J. Qu et al., 2018)
Chitosan/oxidized dextran	poly (ethylene oxide)/poly (propylene oxide)/poly (ethylene oxide)	Curcumin, 5-fluoracil	Cancer	The hydrogel is redox and pH sensitive, which stimulates hydrogel degradation and drug release in the cancerous microenvironment	Release is sustained up to 9 days in vitro depending on the strength of the reductive environment	Injection	(Gao et al., 2016)
Chitosan	sulfobetaine/4-vinylphenylboronic acid /dialdehyde starch	Insulin, nattokinase	Diabetes	Micelles are responsive to glucose, which triggers insulin release	Release is sustained up to 72 hours in vitro depending on glucose levels	Injection	(Wen et al., 2019)