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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Sep 16;14(2):e1756. doi: 10.1002/wnan.1756

Table 3.

Dendrimer Hydrogels for Drug Delivery

Hydrogel Composition Dendimer Composition Drug Disease Release Release Profile Method of Administration Ref.
Polyethylene glycol diacrylate Polyamidoamine Camptothecin Cancer Dendrimers are released slowly with microgel degradation, which is pH dependent, then camptothecin is released via diffusion from the dendrimer core Cumulative release of free CPT reaches 100% at 24 hours, is reduced to 20% at 120 hours via dendrimer hydrogel encapsulation Intravenous injection (J. Wang et al., 2018)
Polyethylene glycol diacrylate Polyamidoamine Brimonidine tartrate Glaucoma Brimonidine free base and salt forms are released in burst from the loosely-crosslinked gel network, and brimonidine encapsulated in the dendrimer core is released slowly over time Cumulative release of free BPT reaches 100% at 24 hours, is reduced to 100% at 48 hours via dendrimer hydrogel encapsulation Topical (J. Wang, Williamson, et al., 2017)
Polyethylene glycol bisazide Polyamidoamine 5-fluorouracil Cancer 5-fluorouracil in the loose hydrogel network is released in burst, whereas the 5-fluorouracil trapped within the dendrimer is released slowly over time Cumulative release of free 5FU reaches 100% at 6 hours, is reduced to ~75% at 12 hours via dendrimer hydrogel encapsulation Intratumoral injection (L. Xu et al., 2017)
Polyethylene glycol diacrylate Polyamidoamine 5-fluorouracil Cancer 5-fluorouracil in the loose hydrogel network is released in burst, whereas the 5-fluorouracil trapped within the dendrimer is released slowly over time Cumulative release of free 5FU reaches 70% in 30 minutes, is reduced to 60% at 1 hour (with a 6 hour plateau at 80%) via dendrimer hydrogel encapsulation Intratumoral injection (J. Wang, He, et al., 2017)
Polyethylene glycol diacrylate Polyamidoamine Camptothecin Cancer Self-cleaving of camptothecin from the dendrimer occurs via ammniolysis, followed by diffusion through the hydrogel Cumulative release of free CPT reaches 100% at 24 hours, is slowed to 100% at 144 hours via dendrimer hydrogel encapsulation Intratumoral injection (J. Wang et al., 2019)