Table 2:
Patient-reported measures at baseline
| Total (n=349) | Urinary urgency with urgency incontinence (n=281) | Urinary urgency without urgency incontinence (n=68) | |
|---|---|---|---|
|
| |||
| Overall LUTS Tool a, b Score ¥ | 47.7 (12.8) | 49.6 (12.6) | 39.9 (10.5) |
| LUTS Tool Frequency Score γ | 55.8 (18.4) | 56.8 (17.8) | 51.8 (20.1) |
| LUTS Tool Post-micturition Score β | 48.4 (26.0) | 48.9 (26.2) | 46.4 (25.0) |
| LUTS Tool Urgency Score γ | 65.0 (18.0) | 68.5 (17.5) | 50.5 (12.5) |
| LUTS Tool Voiding Difficulty Score γ | 28.3 (21.1) | 28.7 (21.1) | 26.8 (21.3) |
| LUTS Tool Pain Score γ | 16.3 (21.7) | 16.3 (21.5) | 16.2 (22.8) |
| LUTS Tool UI Score λ | 45.4 (19.3) | 50.1 (16.6) | 26.6 (17.6) |
| Quality of life due to urinary symptoms (0=Delighted to 6=Terrible) λ | 4.7 (1.1) | 4.8 (1.1) | 4.3 (1.2) |
| PROMIS c Depression (T score) γ | 50.4 (9.0) | 50.9 (9.1) | 48.2 (8.0) |
| PROMIS Anxiety (T score) γ | 51.4 (9.4) | 51.6 (9.6) | 50.4 (8.5) |
| PROMIS Physical Function (T score) γ | 45.7 (10.4) | 45.0 (10.4) | 48.6 (10.2) |
| PROMIS Sleep Disturbance (T score) γ | 51.9 (4.8) | 52.0 (4.9) | 51.4 (4.7) |
| PROMIS GI Diarrhea (T score) γ | 49.7 (9.6) | 50.0 (9.7) | 48.2 (9.5) |
| PROMIS GI Constipation (T score) λ | 52.2 (8.2) | 52.2 (8.1) | 51.9 (8.4) |
| Perceived Stress Scale λ | 13.7 (7.8) | 13.9 (7.7) | 12.8 (7.9) |
| PROMIS GI Bowel Incontinence (raw scale) λ | 5.6 (2.7) | 5.7 (2.8) | 5.2 (2.7) |
Table values are mean (standard deviation). The LUTS Tool scores range from 0 to 100 and were created by combining responses to related symptom severity questions from the LUTS Tool and calculating the Euclidean length of the relevant questions as a measure of overall symptom severity. Higher score means more severity. PROMIS measures T-scores have a mean of 50 and a standard deviation (SD) of 10 by definition and are centered on the US general population. The minimal clinically important differences (MCID) is 3 to 5 points in T-scores across PROMIS measures.
Missing <2%;
Missing 2–5%;
Missing 5–10%;
Missing 17%
LUTS, lower urinary tract symptoms; UI, urinary incontinence; PROMIS, Patient-Reported Outcomes Measurement Information System; GI, gastrointestinal
LUTS Tool: Coyne K, Barsdorf A, Thompson C, et al. Moving towards a comprehensive assessment of lower urinary tract symptoms (LUTS). Neurourology and Urodynamics.31(4):448–454,2012
Helmuth MS, A, Andreev V, Liu G, et al. Use of Euclidean Length to Measure Urinary Incontinence Severity Based on the Lower Urinary Tract Symptoms Tool. American Journal of Obstetrics & Gynecology. 218(3):357–359,2017
PROMIS: Cella D, Riley W, Stone A, et al. The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005–2008. Journal of Clinical Epidemiology.;63(11):1179–1194, 2010