Table 4.

Stability of carmustine (Carmustin Obvius, Carmubris) infusion solutions (0.20 mg/mL, 1.00 mg/mL) diluted in 5% glucose injection solution (freeflex PP/PE bags), stored at 22°C for 11 hours under light protection

Carmustine-containing medicinal product	Initial carmustine concentration (mg/mL)±RSD (%)		% Initial carmustine concentration remaining±RSD (%) (n=9) Measured concentration 0 hour=100%
	Nominal	Measured	3.5 hours	6 hours	8.5 hours	11 hours
Carmustin Obvius	0.2	0.2038 (±1.36)	96.47 (±0.51)	93.39 (±0.52)	91.07 (±0.39)	88.68 (±0.38)
Carmubris		0.2045 (±1.16)	96.08 (±0.31)	93.57 (±0.49)	91.36 (±0.30)	88.88 (±0.32)
Carmustin Obvius	1.0	0.9855 (±1.28)	96.41 (±0.86)	94.59 (±0.64)	92.14 (±0.76)	89.99 (±0.69)

The remaining carmustine concentration is expressed as mean±RSD percentage rate (%) of nine measurements per time point (n=9).

RSD, relative standard deviation.