FIG. 2.

Magnitudes of articular cartilage swelling following CPC uptake, predicted by the ideal Donnan model. (A) Swelling pressures in tissues equilibrated with CPC net-charge variants, calculated using experimentally observed uptake concentrations in bovine cartilage explants following treatment with an equal 30 μM dose of each variant in the surrounding bath. (B) Predicted swelling pressures for CPC-equilibrated tissues across a range of intratissue concentrations, calculated for each net-charge variant.