Table 2.

Empirical Uptake Ratios (R_U) of Cationic Peptide Carriers in Tissue Explants of Varying Fixed Charge Density

	Healthy (100% GAGs) FCD = −0.186 M	Midstage OA (50% GAG-depleted) FCD = −0.084 M	Late-stage OA (90% GAG-depleted) FCD = −0.016 M
CPC +8	55.6 ± 6.8	34.8 ± 2.7	33.1 ± 0.7
CPC +14	366.5 ± 30.3	192.3 ± 23.9	148.3 ± 18.8
CPC +16	258.0 ± 50.8	122.4 ± 21.4	119.1 ± 4.6
CPC +20	181.8 ± 14.2	216.7 ± 16.0	151.7 ± 21.2

Data from Vedadghavami et al.,⁵ presented as mean ± standard deviation.

FCD, fixed charge density; GAG, glycosaminoglycan; OA, osteoarthritis.