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. 2023 Jan 4;613(7943):355–364. doi: 10.1038/s41586-022-05580-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Average ChIP–seq signal for the active regulatory marker H3K27ac, enhancer marker H3K4me1, DNA accessibility and chromHMM enhancer annotations for the top 250 cell-type-specific unmethylated markers for monocytes/macrophages. Average signal for the top 250 markers of other blood cell types (granulocytes and B, T and NK cells) shown as grey lines, for comparison. b, Cell-type-specific markers are enriched for regulatory motifs. Shown are the top TF binding site motifs, enriched among the top 1,000 differentially unmethylated regions per cell type, using HOMER motif analysis. Motifs similar to previous (more significant) hits not included. Shown are HOMER binomial P values. Alv., alveolar; Bronch., bronchial; Endoth., endothelium; Ep., epithelium; Oesoph., oesophagus; Panc., pancreas.