Table 1.

The characteristics of the studies on serum lipids and breast cancer included in this meta-analysis

Author/Year	Country	Type of study	No. of cases/participants	Age (years)	Follow up (years)	Outcome	Menopausal status	Study quality	Adjustments
Chandler et al., 2016	United States	Cohort	864/15,602	>45	19	HDL, LDL, TC, TG	overall	9	Age, race, hormone replacement therapy, cigarette smoking, exercise, alcohol consumption, postmenopausal status, family history of cancer, aspirin use, history of fibrocystic or benign breast disease, total vegetable and fruit intake, history of mammogram, reproductive history including the age of menarche, oral contraceptive use, age, and BMI
Laamiri et al., 2013	Moroccan	Case-control	Case: 400 Control: 400	45.83	2	HDL, LDL, TC, TG	overall	8	Age
Capasso et al., 2010	Italy	Case-control	Case: 210 Control: 289	57.5	NA	HDL	Postmenopause	6	Tobacco use, alcohol abuse, food intake, physical activity grade, parity, age of menarche, menopausal status, oral contraceptive use, hormonal therapy use, personal and familial history of cancer
Furberg et al., 2004	Norwegian	Cohort	708/38,823	58.4	17.2	HDL	Postmenopause, Premenopause	9	Age, BMI, county of residence, parity, height, serum TC, physical activity, blood pressure, serum TG, age at first birth, time since last meal, smoking, energy and fat intake, menopausal status
His et al., 2014	France	Cohort	141/4433	49.5	11.5	HDL, LDL, TC, TG	overall	9	Age, BMI, intervention group, number of dietary records, alcohol intake, physical activity, smoking, education, height, family history of breast cancer, menopausal status, number of full-term, HRT use, energy intake, hyperlipidemia medication use, glycemia
His et al., 2017	Switzerland	Cohort	583/1043	40–65	NA	HDL, LDL, TC, TG	overall	8	Age, BMI, menopausal status, history of breast cancer in first-degree relatives, personal history of benign breast disease, daily alcohol intake, daily glycemic load, daily lipid intake daily energy intake without alcohol
Bjorge, et al., 2010	England	Cohort	4862/287320	58	11	TC, TG	overall	8	Age, BMI, year of birth, smoking, glucose
Agnoli et al., 2010	Italy	Case-control	Case: 236 Control: 556	35-69	13.5	HDL, TG	Postmenopause	9	Age, years from menopause, number of full-term pregnancies, age at first birth, oral contraceptives, hormone therapy, years of education, history of breast cancer in first degree relatives, breastfeeding, smoking, and alcohol consumption
Hoyer et al., 1992	Danish	Cohort	51/5207	30-80	4-26	HDL, LDL, TC, TG	overall	8	Age, BMI, smoking, menopausal status, age at menarche, number of full-term, pregnancies, alcohol, and coffee consumption
Gaard et al., 1994	Norwegian	Cohort	302/31,209	20-54	10.4	LDL	overall	9	Age, BMI, height, menopausal status, smoking
Eliassan et al., 2005	United States	Cohort	3177/71,921	42-69	<10	TC	overall	6	Age, BMI, age at menarche, parity, age at first birth, height, family history of breast cancer and BBD, alcohol consumption, physical activity, menopausal status, age at menopause, HRT use
Kucharaska et al., 2008	United States	Cohort	359/7575	54-64	NA	HDL	Overall	9	Age, race, BMI, age at menarche, smoking, HRT use, age at menopause
Kabat et al., 2009	United States	Cohort	165/4888	50-79	8	HDL, TG	Postmenopause	6	Age, education, race, BMI, oral contraceptive use, HRT use, age at menarche, age at first birth, age at menopause, alcohol, family history of breast cancer, history of breast biopsy, physical activity, energy intake, smoking, randomization of HRT, calcium plus vitamin D, and dietary modification trials, waist circumference, glucose, blood pressure
Inoue et al., 2009	Japan	Cohort	120/18,176	40-69	10.2	HDL, TG	Overall	8	Age, study area, smoking, ethanol intake, serum TC
Iso et al., 2009	Japan	Cohort	178/21,685	40-69	12.4	TC	Overall	9	Age, BMI, smoking, hypertension, diabetes, hyperlipidemia medication use, intake of total vegetable, coffee, and ethanol, public health center
Fagherazzi et al., 2010	France	Cohort	2932/69,088	40-65	12	TC, TG	Overall, Premenopause	6	Age, intake of alcohol, total fat, and energy, oral contraceptives use, age at menarche, age at menopause, number of children, age at first pregnancy, family history of breast cancer, history of BBD, diabetes status, education, HRT use
Kitahara et al., 2011	Korea	Cohort	3805/433,115	30-95	12.7	TC	Overall, Postmenopause, Premenopause	8	Age, BMI, smoking, alcohol intake, glucose, hypertension, physical activity
Bosco et al., 2012	United States	Cohort	1228/49,172	21-69	10.5	TC	Overall, Postmenopause, Premenopause	7	Age, BMI, education, physical activity, obesity, Type 2 diabetes, hypertension
Melvin et al., 2012	Swedish	Cohort	6105/234,494	>25	8.3	HDL, LDL, TC, TG	Overall	7	Age, parity, level of glucose, TG, TC, fasting status, and socioeconomic status
Strohmaier et al., 2013	European	Cohort	5228/288,057	40.3-47.5	11.7	TC	Overall	8	Age, BMI, smoking
Ha et al., 2009	Korea	Cohort	741/170,374	40- 64	8.84	TC	Postmenopause	8	Age, age at menarche, BMI, nulliparity, hormone replacement therapy, duration of breastfeeding, smoking habit, and alcohol consumption
Moorman et al., 1998	United States	Case-control	Case: 196 Control:	NA	NA	HDL	Postmenopause, Premenopause	8	Education, smoking status, BMI, alcohol consumption, and history of benign breast disease
Osaki et al., 2011	Japan	Cohort	78/15,386	55	9.1	HDL, TG	Overall	9	Age, smoking status, heavy drinking, presence of metabolic syndrome or pre-metabolic syndrome of each definition.
Borena et al., 2010	European	Cohort	5006/256,512	44.2	11.9	TG	Overall	9	Baseline age, BMI, and smoking status
Manjer et al., 2001	European	Cohort	409/9738	49.6	15	TC	Postmenopause, Premenopause	9	Age, nulliparity, current oral contraceptive use, current HRT, smoking, alcohol consumption, height, and weight