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. Author manuscript; available in PMC: 2023 Jan 4.
Published in final edited form as: Cell Stem Cell. 2022 Aug 4;29(8):1156–1158. doi: 10.1016/j.stem.2022.07.002

Figure 1. Successive inflammatory experiences via multiple clinical forms may impair the ability of LT-HSCs to self-renew and may accelerate their biological age.

Figure 1.

Bogeska et al. demonstrated that repeated exposure to inflammation hinders LT-HSC self-renewal and increases the biological age of these cells. This finding has implications for clinical sources of inflammation experienced throughout life, such as infection, ulcerative colitis, cardiovascular disease, and arthritis. This figure was created using BioRender.com.