Table 2.

Characteristics of genetic variants associated with depression and anxiety in UK Biobank.

Trait	SNP	CHR	Position	$p$-Value	Allele 1	Allele 2	OR	SE	Frequency
Depression	rs1432639	1	72813218	$4.6\times {10}^{–15}$	A	C	1.04	0.005	0.63
	rs12129573	1	73768366	$4.0\times {10}^{–12}$	A	C	1.04	0.005	0.37
	rs2389016	1	80799329	$1.0\times {10}^{–8}$	T	C	1.03	0.0053	0.28
	rs4261101	1	90796053	$1.0\times {10}^{–8}$	A	G	0.97	0.005	0.37
	rs9427672	1	197754741	$3.1\times {10}^{–8}$	A	G	0.97	0.0058	0.24
	rs11682175	2	57987593	$4.7\times {10}^{–9}$	T	C	0.97	0.0048	0.52
	rs1226412	2	157111313	$2.4\times 10^{–8}$	T	C	1.03	0.0059	0.79
	rs7430565	3	158107180	$2.9\times {10}^{–9}$	A	G	0.97	0.0048	0.58
	rs34215985	4	42047778	$3.1\times {10}^{–9}$	C	G	0.96	0.0063	0.24
	rs11135349	5	164523472	$1.1\times {10}^{–9}$	A	C	0.97	0.0048	0.48
	rs4869056	5	166992078	$6.8\times {10}^{–9}$	A	G	0.97	0.005	0.63
	rs9402472	6	99566521	$2.8\times {10}^{–8}$	A	G	1.03	0.0059	0.24
	rs10950398	7	12264871	$2.6\times {10}^{–8}$	A	G	1.03	0.0049	0.41
	rs12666117	7	109105611	$1.4\times {10}^{–8}$	A	G	1.03	0.0048	0.47
	rs1354115	9	2983774	$2.4\times {10}^{–8}$	A	C	1.03	0.0049	0.62
	rs10959913	9	11544964	$5.1\times {10}^{–9}$	T	G	1.03	0.0057	0.76
	rs7856424	9	119733595	$8.5\times {10}^{–9}$	T	C	0.97	0.0053	0.29
	rs7029033	9	126682068	$2.7\times {10}^{–8}$	T	C	1.05	0.0093	0.07
	rs61867293	10	106563924	$7.0\times {10}^{–10}$	T	C	0.96	0.0061	0.2
	rs1806153	11	31850105	$1.2\times {10}^{–9}$	T	G	1.04	0.0059	0.22
	rs4074723	12	23947737	$3.1\times {10}^{–8}$	A	C	0.97	0.0049	0.41
	rs4143229	13	44327799	$2.5\times {10}^{–8}$	A	C	0.95	0.0091	0.92
	rs12552	13	53625781	$6.1\times {10}^{–19}$	A	G	1.04	0.0048	0.44
	rs4904738	14	42179732	$2.6\times {10}^{–9}$	T	C	0.97	0.0049	0.57
	rs915057	14	64686207	$7.6\times {10}^{–10}$	A	G	0.97	0.0049	0.42
	rs10149470	14	104017953	$3.1\times {10}^{–9}$	A	G	0.97	0.0049	0.49
	rs8025231	15	37648402	$2.4\times {10}^{–12}$	A	C	0.97	0.0048	0.57
	rs8063603	16	6310645	$6.9\times {10}^{–9}$	A	G	0.97	0.0053	0.65
	rs7198928	16	7666402	$1.0\times {10}^{–8}$	T	C	1.03	0.005	0.62
	rs7200826	16	13066833	$2.4\times {10}^{–8}$	T	C	1.03	0.0055	0.25
	rs11643192	16	72214276	$3.4\times {10}^{–8}$	A	C	1.03	0.0049	0.41
	rs17727765	17	27576962	$8.5\times {10}^{–9}$	T	C	0.95	0.0088	0.92
	rs62099069	18	36883737	$1.3\times {10}^{–8}$	A	T	0.97	0.0049	0.42
	rs11663393	18	50614732	$1.6\times {10}^{–8}$	A	G	1.03	0.0049	0.45
	rs1833288	18	52517906	$2.6\times {10}^{–8}$	A	G	1.03	0.0054	0.72
	rs12958048	18	53101598	$3.6\times {10}^{–11}$	A	G	1.03	0.0051	0.33
	rs5758265	22	41617897	$7.6\times {10}^{–9}$	A	G	1.03	0.0054	0.28
Anxiety	rs79928194	2	233649290	$1.26\times {10}^{-6}$	T	C	0.862	0.0515	0.905
	rs342422	5	83470986	$1.28\times {10}^{-6}$	A	G	0.92	0.036	0.53
	rs2451828	5	7748796	$7.37\times {10}^{-7}$	T	C	1.34	0.156	0.019
	rs6462203	7	3676002	$1.09\times {10}^{-7}$	A	C	0.901	0.0345	0.265
	rs16916239	8	87643741	$8.96\times {10}^{-7}$	A	G	0.903	0.037	0.783
	rs113209956	9	2511193	$6.36\times {10}^{-8}$	T	C	0.828	0.057	0.085
	rs1458103	11	81047274	$6.19\times {10}^{-8}$	A	C	0.898	0.0345	0.741
	rs11855560	15	41024303	$6.96\times {10}^{-7}$	T	C	1.089	0.0365	0.469
	rs6030245	20	41070559	$5.06\times {10}^{-7}$	T	C	1.12	0.049	0.795

Note: The 37 risk alleles of depression were selected based on Wray et al.’s study,³⁰ and the nine risk alleles of anxiety were selected based on Meier et al.’s study.³¹ The ORs, p-values, and frequencies are based on selected GWASs. CHR, chromosome; GWAS, genome-wide association study; OR, odds ratio; SNP, single-nucleotide polymorphism.