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. 2022 Dec 14;20(1):582–592. doi: 10.1021/acs.molpharmaceut.2c00815

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© 2022 The Authors. Published by American Chemical Society

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Representative T2-weighted MRI images in NRG mice with U251-Luc human GBM tumors at 28 d after CED of (A) normal saline, (B) unlabeled AuNPs (4 × 10¹¹ AuNPs), or (C) 1.1 MBq of ¹⁷⁷Lu-AuNPs (4 × 10¹¹ AuNPs). Tumors in the brain in control mice are indicated by the arrows. There was no visible tumor in the brain in mice treated with ¹⁷⁷Lu-AuNPs. (D) Tumor volume measured by analysis of MRI images. Horizontal lines indicate the mean ± SEM (n = 8–10).