Table 2. Blood Biochemistry and Hematology at 14 d Post-CED of 177Lu-AuNPs or Normal Saline in NRG Mice with Orthotopic U251-Luc Human GBM Tumorsa.
| parameterb | 177Lu-AuNPs | normal saline |
|---|---|---|
| ALT (U/L) | 27.0 ± 2.9 | 19.8 ± 1.7 |
| CRE (μmol/L) | 18.0 ± 0.0 | 18.3 ± 0.5 |
| GLU (mmol/L) | 8.5 ± 4.2 | 12.6 ± 1.3 |
| TP (g/L) | 45.0 ± 2.1 | 47.3 ± 2.6 |
| ALP (U/L) | 55.8 ± 6.3 | 61.0 ± 6.4 |
| BUN (mmol/L) | 7.2 ± 1.5 | 8.2 ± 0.4 |
| HGB (g/dL) | 12.1 ± 1.4 | 13.1 ± 0.6 |
| HCT (%) | 38.0 ± 1.3 | 38.2 ± 1.2 |
| RBC (×1012/L) | 8.6 ± 0.3 | 8.7 ± 0.3 |
| WBC (×109/L) | 2.4 ± 2.9 | 0.9 ± 0.3 |
| PLT (×109/L) | 428.3 ± 166.1 | 441.3 ± 227.8 |
a
Mice received CED of 1.5 MBq (5 μL) of 177Lu-AuNPs (4 × 1011 AuNPs) or normal saline (5 μL). n = 4–5.
b
ALT: alanine aminotransferase; CRE: creatinine; GLU: glucose; TP: total protein; ALP: alkaline phosphatase; BUN: blood urea nitrogen; HGB: hemoglobin; HCT: hematocrit; RBC: red blood cells; WBC: white blood cells; and PLT: platelets. No significant differences (P > 0.05) were found in any of these parameters for mice receiving 177Lu-AuNPs or normal saline.