TABLE 1.

mRNA correlation results

Gene group	Gene	Gene auto‐correlation	TME cross‐correlation		OA cross‐correlation		Direction of correlation
		(R 2)	(R 2)	(p)	(R 2)	(p)
Opioid	OPR‐M1	0.82	0.11	.230	0.10	.245	+1
	OPR‐K1	0.72	0.30	.034 a	0.23	.070	+1
Dopamine	DR‐D1	0.69	0.16	.140	0.15	.154	+1
	DR‐D2	0.88	0.12	.207	0.36	.018 a	+1
	DR‐D3	0.44	0.19	.104	0.04	.475	+1
	DR‐D5	0.44	0.06	.379	0.10	.245	−1
Adrenaline	ADR‐A‐1A	0.45	0.16	.140	0.05	.431	+1
	ADR‐A‐1B	0.94	0.02	.619	0.19	.104	−1
	ADR‐A‐2A	0.78	0.13	.188	0.31	.029 a	+1
	ADR‐A‐2C	0.89	0.08	.307	0.06	.379	+1
	ADR‐B‐2	0.54	0.17	.129	0.21	.086	+1
Serotonin	5‐HTR‐1A	0.90	0.05	.431	0.19	.104	−1
	5‐HTR‐1E	0.82	0.06	.379	0.08	.307	−1
	5‐HTR‐2C	0.90	0.23	.070	0.09	.277	+1
	5‐HTR‐3B	0.48	0.19	.104	0.19	.104	−1
	5‐HTR‐5A	0.60	0.27	.047 a	0.30	.034 a	−1
	5‐HT‐4	0.73	0.07	.340	0.09	.277	+1
	5‐HTR‐7	0.80	0.26	.058	0.13	.188	+1

Abbreviations: OA, osteoarthritis; TME, third molar extraction.

^a Statistically significant correlations.