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. 2022 Jun 25;43(17):5167–5179. doi: 10.1002/hbm.25992

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© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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BOLD activations in response to nociceptive laser stimuli in S1. (a) Nociceptive laser stimuli elicited significant activations in the primary/secondary somatosensory cortices (S1/S2), thalamus, anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and insula in both PHN patients (top panel) and HC (bottom panel). (b) The comparison of BOLD percentage changes in bilateral S1. When the bilateral S1 (MNI anatomical template) were used as the ROIs, two‐way ANOVA analysis revealed that HC exhibited a significant activation focus in contralateral S1 to the stimulated (left) hand; while PHN patients showed greater activation in ipsilateral S1 than HC (ns, not significant; *p < .05).