Figure 2.
Proteins elevated in vampire bat serum versus human plasma. (A) Average protein abundance of 361 proteins in vampire bat serum. (B) Reported protein abundance of 3222 proteins reported on the Human Plasma Atlas. (C) Innate immunity proteins with bat and human ranks. The * for MBL1 and APOR is to indicate that these are not human proteins and not present in human plasma. (D) Proteasome related to proteins with bat and human ranks. (E) Redox related proteins with bat and human ranks. (F) Other uncategorized (“other”) proteins of interest with bat and human ranks. All protein ranks are given in Supplemental Table S5, while just select proteins here are described in Supplemental Table S6. Abbreviations: (C) ANG, angiogenin; APOR, apolipoprotein R; ARF1, ADP-ribosylation factor 1; BPIFA2, BPI fold-containing family A member 2; CAMP, cathelicidin antimicrobial peptide; CREG1, protein CREG1; DMBT1, deleted in malignant brain tumors 1 protein; EEF1A1, elongation factor 1-alpha 1; GBP2, guanylate-binding protein 2; GBP6, guanylate-binding protein 6; GBP7, guanylate-binding protein 7; IFI6, interferon alpha-inducible protein 6; MBL1, mannose-binding protein A; SFTPD, pulmonary surfactant-associated protein D. (D) PSMA1, proteasome subunit alpha type-1; PSMA2, proteasome subunit alpha type-2; PSMA3, proteasome subunit alpha type-3; PSMA4, proteasome subunit alpha type-4; PSMA5, proteasome subunit alpha type-5; PSMA6, proteasome subunit alpha type-6; PSMA7, proteasome subunit alpha type-7; PSMB1, proteasome subunit beta type-1; PSMB2, proteasome subunit beta type-2; PSMB3, proteasome subunit beta type-3; PSMB4, proteasome subunit beta type-4; PSMB5, proteasome subunit beta type-5; PSMB6, proteasome subunit beta type-6; PSMD2, 26S proteasome non-ATPase regulatory subunit 2; RAD23A, UV excision repair protein RAD23 homologue A; RPS27A, ubiquitin-40S ribosomal protein S27a; USP14, ubiquitin carboxyl-terminal hydrolase 14. (E) GPX1, glutathione peroxidase 1; GPX3, glutathione peroxidase 3; PRDX1, peroxiredoxin-1; PRDX2, peroxiredoxin-2; PRDX6, peroxiredoxin-6; RFESD, Rieske domain-containing protein; SOD1, superoxide dismutase [Cu–Zn]; TXN, thioredoxin; VNN2, vascular noninflammatory molecule 2; VNN3, vascular noninflammatory molecule 3. (F) ACE, angiotensin-converting enzyme; ADIPOQ, adiponectin; AFP, alpha-fetoprotein; AHCY, adenosylhomocysteinase; CD177, CD177 antigen; CD97, CD97 antigen; CLCA1, calcium-activated chloride channel regulator 1; DPEP1, dipeptidase 1; EIF5A2, eukaryotic translation initiation factor 5A-2; FCGBP, IgGFc-binding protein; GCLM, glutamate–cysteine ligase regulatory subunit; HIST2H2BE, histone H2B type 2-E; HSPA2, heat shock-related 70 kDa protein 2; HSPA4, heat shock 70 kDa protein 4; HYAL1, hyaluronidase-1; IMPDH2, inosine-5′-monophosphate dehydrogenase 2; ITIH2, interalpha-trypsin inhibitor heavy chain H2; ITIH3, interalpha-trypsin inhibitor heavy chain H3; ITIH4, interalpha-trypsin inhibitor heavy chain H4; KLK1, kallikrein-1; LIPG, endothelial lipase; PAFAH1B2, platelet-activating factor acetylhydrolase IB subunit beta; PCBP1, poly(rC)-binding protein 1; PF4, platelet factor 4; SERPINB10, serpin B10; SMPD1, sphingomyelin phosphodiesterase; SRI, sorcin; TFRC, transferrin receptor protein 1; TMPRSS9, transmembrane protease serine 9.