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. 2023 Jan 4;18(1):e0266985. doi: 10.1371/journal.pone.0266985

Table 2. Number and percentage of patients per age groups, per sex, per Elixhauser comorbidities for young adult patients with ARDS and non severe young adult patients.

Risk ratio associated in uni- and multivariable analysis.

Variables ARDS NO SEVERE Univariable analysis Multivariable analysis
ages 18–49 ages 18–49
n = 1001 n = 10107 Risk Ratio with CI (95%) p-value Risk Ratio with CI (95%) p-value
n (%) n (%)
Age groups, reference: 18 to 25 years old
18to25 43 (4.3) 1207 (11.9) 2.9 [2.1; 4.1] <0.001 not include
26to49 966 (96.5) 8900 (88.1)
Sex, reference: female
female 327 (32.7) 4427 (43.8) 1.7 [1.3; 2.2] <0.001 1.71 [1.2; 2.4] 0.003
male 672 (67.1) 5680 (56.2)
Comorbidities (Elix Hauser class), ICD code from -365 days before to + 90 days after admission
AIDS/HIV 12 (1.2) 121 (1.2) 1 [0.5; 1.9] 0.987 not include
Alcohol abuse 59 (5.9) 895 (8.9) 1 [0.7; 1.4] 0.92 not include
Cancer 37 (3.7) 280 (2.8) 1.3 [0.9; 1.7] 0.164 not include
Chronic pulmonary disease 219 (21.9) 1406 (13.9) 1.8 [1.6; 2.1] <0.001 1.6 [1.3; 2.0] <0.001
Congestive heart failure 143 (14.3) 532 (5.3) 3.4 [2.6; 4.4] <0.001 2.2 [1.4; 3.6] 0.001
Diabetes 322 (32.2) 1691 (16.7) 2.5 [2; 3.1] <0.001 1.9 [1.4; 2.4] <0.001
Drug abuse 65 (6.5) 828 (8.2) 1 [0.8; 1.3] 0.997 not include
Hypertension 382 (38.2) 2274 (22.5) 2.5 [2; 3.2] <0.001 1.4 [0.98; 1.9] 0.062
Hypothyroidism 45 (4.5) 431 (4.3) 1.4 [1; 2.1] 0.077 not include
Liver disease 179 (17.9) 960 (9.5) 2.1 [1.6; 2.8] <0.001 1.6 [1.1; 2.3] 0.01
Obesity 533 (53.2) 2759 (27.3) 2.9 [2.2; 3.9] <0.001 2.8 [2.0; 4.0] <0.001
Paralysis 64 (6.4) 162 (1.6) 2.9 [2.3; 3.6] <0.001 3.7 [2.5; 5.5] <0.001
Peptic ulcer disease 36 (3.6) 60 (0.6) 4.2 [2.9; 6] <0.001 3.7 [2.1; 6.5] <0.001
Peripheral vascular disease 37 (3.7) 184 (1.8) 2.7 [1.7; 4.2] <0.001 1.2 [0.7; 2.1] 0.485
Psychoses 52 (5.2) 599 (5.9) 1.1 [0.8; 1.4] 0.513 not include
Renal failure 131 (13.1) 590 (5.8) 2.4 [1.9; 2.9] <0.001 1.3 [0.9; 1.8] 0.158
Valvular disease 92 (9.2) 346 (3.4) 2.9 [2.1; 4] <0.001 1.9 [1.1; 3.3] 0.025