Table 1. IC₅₀ values of clonal cell lines derived from A9/BT, A10/AT3, A16/AT1, A21/AT4, G3/BT and N3/BT isolates treated with buparvaquone.

	IC50 values (ng/mL)
Clone ID	A9/BTb	A10/AT3a	A16/AT1b	A21/AT4a	G3/BTb	N3/BTb
1	0.86	13.89	1.85	16.75	2.89	3.28
2	0.91	29.78	1.61	25.53	9.21 *	0.18
3	0.89	25.94	0.71	125.70 *	1.28	0.95
4	1.15	16.99	0.75	6.36	7.48	14.19 *
5	2.12 *	12,62	2.70	63.72	3.19	10.70 *
6	1.67 *	47.37	1.90	18.95	2.61	2.31
7	0.69	77.74	1.80	13.33	2.69	9.66
8	0.50	99.85 *	1.81	209.10 *	0.62	1.05
9	1.34	137.70 *	3.21 *	30.66	0.92	6.20
10	0.78	63.95	4.66 *	29.14	13.61 *	0.51

(*) indicates clonal cell lines which were used for sequence analysis.

(^{a, b}) Different lower case superscript letters indicate statistical significance (P < 0.05). IC₅₀ values obtained from the clones of the cell lines A10/AT3 and A21/AT4 was significantly different from IC₅₀ values of the clones of the cell lines A9/BT, A16/AT1, G3/BT and N3/BT. There was no significant difference in IC₅₀ values between A10/AT3 and A21/AT4, and among the A9/BT, A16/AT1, G3/BT and N3/BT (P > 0.05).